HISTOPATHOLOGICAL MARKERS PROFILE OF LENTIGO MALIGNA/LENTIGO MALIGNA MELANOMA IN A CENTRE IN BUCHAREST - ROMANIA FROM 2003 TO 2013. HIGHLIGHTING THE HISTOPATHOLOGICAL PROGNOSTIC MARKERS
Abstract:
Lentigo maligna is the melanoma “in situ”. When invades the dermis, it becomes lentigo maligna melanoma and the prognostic features are identical to all other melanomas according to size and level of invasion. The rate of progression of LM to LMM is 5-50%. LMM represents 4-15% of all malignant melanomas and 10-26% of melanomas of the head and neck. Objectives: histopathological profile analysis, with emphasis on histopathological prognostic markers. They were studied the associations between histopathological markers. Method: Analysis of 28 histopathological reports having diagnosis of LM/LMM from the archive of the Pathology Department - Colentina Clinical Hospital in Bucharest (from 2003 to 2013). Statistical analysis of data was done with SPSS 19.0. Graphs were made with Tableau 8.2. Results: In the study, there are 20 women and 8 men with a mean age of 66 years; 24 lesions are to the head; pT staging is as follows - pT is-7cases, pT1-14 cases pT2- 1 case and pT 3 and 4, 2 cases each. Mean tumour thickness is 1,03mm; The mitotic index is greater than 6 mitoses / HPF in two cases. Conclusions: 20/28 cases are diagnosed in early stages, curable surgically. Demographics such as age and female preponderance are similar to those described in the literature.
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