The present paper aims at drawing attention on the implications that chronic kidney disease (CKD) syndrome has on oral health. This extremely complex syndrome, a long-term condition, characterised by the gradual loss of the kidney excretory function and the impaired homeostasis of the internal environment, causes a series of morphological-clinical dental aspects in relation to the stage in the evolution of the underlying disease. In this paper we presented data in the literature relating to the oral manifestations of the CKD as well as some ways to prevent and manage them. Prevention and management are possible only if the stage in the evolution of the disease is precisely known. It is the same with the correct assessment of the risks that can be posed by a dental intervention, even a minimal one, for the health of the patient suffering from CKD. It is necessary that the dental practitioner should know the biological constants of the patient (bleeding time, hematorcrit, hemoglobin, prothrombin time, blood pressure etc.). Moreover, any treatment involves the nephrologist who has the patient under observation and treatment.