The aim of the paper is to highlight the clinical changes (mainly mycoses) in the tongue in patients with general conditions as well as the possible etiopathogenic mechanisms and the correlation between them and local and general risk factors. The method is represented by a rigorous study conducted on 500 patients of both genders between 2010 and 2013. General conditions as well as primary or associated lingual lesions were clinically detected in 221 patients. The results indicated a high rate of primary or associated glossitis as well as a significant number of other types of lingual disorders. The data of the study are presented in graphs and tables. The important conclusion of the paper is the high rate of primary or associated fungal glossitis in patients with a history of chronic disease, as well as the existence of comorbidity-related risk factors and aggravating local-regional factors. The rate of occurrence of other types of glossitis is significantly lower.