Statistical indicator YPLL (Years Potential Life Lost), proposed in the Global Burden of Disease 1990 study to estimate the burden of disease in a population, moves target from classical focus on the occurrence of deaths to focus on the losses caused by these deaths, assessing premature mortality. The purpose of research is to estimate the impact of premature death caused by major cardiovascular diseases on health of the adults of the Republic of Moldova. This research is a population descriptive study. The study estimated that the population of working age (up to 62 years old) in Moldova accounts for 70% of the major cardiovascular diseases of the average YPLL (2008-2012). Systematic assessment of potential indicators (PYLL, DALY) provides added safety for prioritizing interventions and evidencebased decision-making regarding the management of cardiovascular prevention in the Republic of Moldova.