anastomotic leakage (AL) is a severe complication in colorectal surgery, and C-reactive protein (CRP) level can be a predictive marker of this complications. Material and method: this retrospective study analyses the evolution of 341 patients with colorectal cancer and primary anastomosis between 2003 and 2012, performed in the Ist Surgical Clinic, Emergency Academic Hospital Sibiu. Results: 7,3% of 341 patients developed AL, the mean day was 8,8 day postoperative of the patients with AL, 20 (80%) underwent reoperation, 20% of AL patients were treated conservatively. The high mortality in patients with AL (8%) caused by sepsis, versus 3,2% in larger group without AL and sepsis (p=0,20). The study of the serum CRP levels and WBC of patients say that CRP level in the two groups a peak on day 2, and in presence of AL, the CRP level not show a real decrease during the next few days. We observed high CRP levels in patients with pneumonia and other postoperative inflammations or sepsis. Conclusions: The serum CRP level is a relevant marker in diagnosis of the postoperative complications after colorectal resections.