The early diagnosis of pancreatic necrosis is particularly important for the establishment of the subsequent therapeutic management. Recent studies show that pancreatic necrosis occurs in the first 48-72 hours from the onset of acute pancreatitis.(1) Therefore, markers for pancreatic necrosis reaching a maximum concentration in serum or urine within the first 24-48 hours are searched for. The most studied are CRP PMN elastase, TNF factor, interleukin-6, α1-antitrypsin, trypsinogen, TAP (trypsinogen activating peptide), and serum amyloid pancreatic ribonuclease.(2) While CRP is available in all laboratories, the other markers are not available in the clinic and occur only in the clinical trails regarding their efficacy.(3,1,4)