C-REACTIVE PROTEIN (CRP) AND ITS PREDICTIVE ROLE
Abstract:
The early diagnosis of pancreatic necrosis is particularly important for the establishment of
the subsequent therapeutic management. Recent studies show that pancreatic necrosis occurs in the first
48-72 hours from the onset of acute pancreatitis.(1) Therefore, markers for pancreatic necrosis reaching
a maximum concentration in serum or urine within the first 24-48 hours are searched for. The most
studied are CRP PMN elastase, TNF factor, interleukin-6, α1-antitrypsin, trypsinogen, TAP (trypsinogen
activating peptide), and serum amyloid pancreatic ribonuclease.(2) While CRP is available in all
laboratories, the other markers are not available in the clinic and occur only in the clinical trails
regarding their efficacy.(3,1,4)
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