SYSTEMIC ANTIMICROBIAL THERAPY AS AN ADJUNCT TO SCALING AND ROOT PLANING
Abstract:
The association of the mechanical treatment with a general antimicrobial one can lead to the
consolidation of the obtained results. The present clinical trial was performed in order to study the
effects of systemic administration of metronidazole and amoxicillin as an adjunct to scaling and root
planing (SRP) in patients with generalized chronic periodontal disease. The 50 patients were randomly
distributed into 2 different samples of 25 subjects each: one received systemic antimicrobian treatment
and the 2nd sample of subjects received a placebo drug. In each patient, 2 quadrants (1 in the maxilla
and 1 in the mandible) were exposed to SRP and the contralateral quadrants were left without
subgingival instrumentation. SRP combined with systemic administration of amoxicillin-metronidazole
was the most efficient in improving the clinical parameters of the periodontal disease
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