THE INFLUENCE OF BACKGROUND THERAPY WITH LEUKOTRIENE INHIBITORS ON CLINICAL SPIROMETRIC PARAMETERS AND ON EXHALED NITRIC OXIDE IN THE CHILDREN WITH ASTHMA
Abstract:
The installation of bronchial remodelling process within the chronic inflammatory process in asthma has a significant result on both: the severity of the clinical signs and also on the response to the treatment. A key argument for the support of diagnosis and asthma severity is the demonstration of the presence of bronchial obstruction in terms of spirometry and, more recently, through the demonstration of eosinophilic inflammation with the help of values of nitric oxide in exhaled air. Both methods explore the inflammatory process of the airways. The pathogenesis of asthma is increasingly well understood, but increasingly dynamic. Therefore, there are being developed new classes of drugs. Numerous studies attempt to demonstrate the effectiveness of different classes of drugs, and chronic side effects of these therapies in children with asthma. A great progress is being made in the study of two major classes of drugs currently used to treat asthma: inhaled corticosteroids (CSI) and leukotriene inhibitors (ILT), recommended as a treatment medication in early stages of the disease. The effect of this therapy in the inflammatory process correlates with the levels of nitric oxide in exhaled air and with the values of the parameters determined by spirometry. One objective of this study is precisely to evaluate the role of anti-inflammatory treatment with leukotriene inhibitors (ILT) associated with inhaled corticosteroid (CSI) in maintaining asthma control. Another objective of the study is to determine the role of exhaled nitric oxide (NO) in monitoring the development of asthma/ recurrent wheezing in correlation with spirometry (old method established).
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