Teeth are good indicators for exposure to heavy metals and for evaluation of nutritional status. To determine the trace elements in carious dentin of permanent teeth we have used inductively coupled plasma with mass spectrometry (ICP-MS). For this purpose, there were collected permanent teeth decayed (premolars and molars) from adults (men), aged 40 to 60 years old (N = 30), in 3 different areas: 10 samples from the Câmpia Turzii area (CT area exposed to Pb), 10 samples from the area of Satu-Mare (SM area exposed to Pb) and 10 samples collected from Cluj-Napoca (control group CJ). We have analyzed the concentrations of 8 elements (macroelements, trace elements and heavy metals: Ca, Mg, Cu, Fe, Zn, Mn, Cd, and Pb) in the dentin of permanent carious teeth. The concentrations of Fe, Zn, Mn, Mg, Cd and Pb were higher in carious permanent teeth from exposed subjects comparing with the control group CJ. Cu and Zn levels are higher in CT group. According to these results, we can conclude that trace elements and heavy metals are positively associated with caries. The concentrations of trace elements found in teeth often provide information about disability or illness, poisoning or contamination.