Current studies have shown that elevated C-reactive protein (CRP) promotes atherogenesis and the development of cardiovascular and cerebrovascular diseases. The aim of this study was to investigate the presence of chronic inflammation by measuring serum CRP as atherogenic factor in patients suffering from subclinical hypothyroidism (HoTS) and stroke versus patients with stroke and without HoTS. The study was conducted on 154 patients who had suffered a stroke and a control group consisting of 15 patients with normal thyroid function, without signs and symptoms of stroke. The results have shown that increased levels of CRP have been associated with stroke and HoTS and demonstrate the important role of inflammation in the development of atherosclerosis (ATS) in these patients