Cleaning products are used in everyday life in schools bringing numerous benefits, such as dust removal or preventing the spread of infections. However, exposure to chemicals that are constituents of these products may cause functional and organic damage. Since the exposure depends on the product type and the conditions under which they are used, the aim of this study was to assess cleaning procedures used in schools from Romania, and also to evaluate comfort parameters, critical in the formation and evolution of indoor pollutants. The experimental study was carried out in two classrooms by applying a checklist for classrooms and measurements of comfort parameters. Dry cleaning activities and sweeping the floors were the most frequent; also, not using vacuums were considered quite ineffective. Poor ventilation and comfort parameters that reached certain levels, supplied good conditions for the formation of secondary organic aerosols, and present a risk to children’s health.