With the onset of the HIV epidemic, there was an alarming increase of cases with pulmonary (3%) and extra-pulmonary tuberculosis (TB) as a result of the lymphohematogenous dissemination of the primary pulmonary infection. In the initial stages of HIV infection, the localized pulmonary TB is the most frequent, that is attributed to a reactivation of an infection with Mycobacterium tuberculosis. In the advanced stages of the immunosuppression, the TB infection is a primary one, which is produced mainly by atypical mycobacteria. About 120 species of non-tuberculous mycobacteria are known to be able to cause infections with lung, lymph node, bone, soft tissue, skin localization and central nervous system impairment. In TB endemic countries (with over 50 cases/100.000 persons) the risk of extra-pulmonary TB infection is significantly associated with the multidrug resistance of the mycobacteria. We present the case of an HIV positive patient detected from a particular lymph node TB in terms of evolution and site.