TSH AND FT4 VALUES ANALYSIS BY AGE AND GENDER IN PATIENTSWITH HYPOTONIC SYNDROME USING CRT ALGORITHM: A RETROSPECTIVE STUDY
Abstract:
Deficiency of thyroid hormones associates muscle weakness. Muscle weakness represents an
important clinical sign that can occur in cases of subclinical hypothyroidism manifested only by
hypotonic syndrome. In our retrospective study performed for 146 cases admitted in the Pediatric
Clinical Hospital from Sibiu we have analyzed the levels dynamics of TSH and FT4 to determine
whether there are statistically significant particularities by age and gender in pediatric patients
suspected with developmental disorders (hypotonic syndrome). We used T-test, Mann-Whitney, ANOVA
and CRT decision algorithm and we pointed that the differences in averages of FT4 and TSH between
ages 0-1,1-2,2-6 and 6 years are not statistically significant and cohort studies are still necessary. FT4
values are influenced rather by gender and TSH by age. The suspicion of subclinical hypothyroidism
should be considered especially in children with hypotonic syndrome even when the values are in the
range 3.5-4.5 uIU/mL if TSH.
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