THE ROLE OF LOCO-REGIONAL SURGERY IN WOMEN WITH METASTATIC BREAST CANCER AT PRESENTATION
Abstract:
Primary metastatic breast cancer (PMBC) is a poor prognosis disease with 5-year overall
survival (OS) in 24-39%. The “dogma” of surgery in PMBC was challenged by retrospectives studies
which suggested that loco-regional surgery (LRS) can improve OS. Clinical advantages are still
controversial. The aim of this study is to determine the place of LRS in oncological outcomes of these
patients. Relevant PubMed data between 2002-2017 on LRS in PMBC were registered. Twenty-nine
publications, 78239 patients were included, 44.4% underwent surgery. Median OS in LRS group was
36.7 months compared to 25.1 month for systemic treatment (ST) group. These findings correspond with
those of one randomized trial. The timing and quality-of-life remains uncertainty. LRS may increase OS
in PMBC. LRS is reserved for uncontrolled local disease, it should be proposed for women with
oligometastatic disease, younger age, indolent PMBC and for responders of ST.
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