NEUROLOGICALMALFORMATION RELATED TO HUMAN IMMUNODEFICIENCY VIRUS: CASE REPORT
Abstract:
Mother to child HIV transmitted infections are dramatically decreasing. However, follow-up
studies of growing children perinatally exposed to antiretrovirals are limited. We report a case of a
child born with a brain defect and macrocephaly in the first year of life. His mother on age 21 was
perinatally infected with human immunodeficiency virus and was diagnosed with acute hepatitis B and
syphilis during pregnancy, when she received zidovudine, lamivudine, nevirapine and a course of
penicillin. Due to efficient prophylaxis, the child was not infected with human immunodeficiency virus
and syphilis, though a Dandy-Walker brain defect was revealed. Regular follow-up of HIV infected
pregnant women for neurological fetal defects and systematically reported data should improve the
management of risks in perinatally exposed children.
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