THE SYNDROME OF ABNORMAL CHROMATIN CLUMPING -CASE REPORT
Abstract:
The syndrome of abnormal chromatin clumping is a rare morphological entity consisting of an exaggerated clumping of nuclear leukocytes chromatin. We report the case of an 81 year-old man admitted for persistent anemia-related symptoms. Complete blood count reveals low hemoglobin, low number of platelet, normal number of white blood, leukoerythroblastic picture, hypercellular bone marrow with abnormal chromatin clumping in myeloid series cells, small megakaryocytes, with non-lobulated nucleus. Readmitted after 7 months, the patient presents leukocytosis with differential deviated to left up, without basophilia or monocytosis, hypercellular bone marrow, increased granulocytic series with abnormal chromatin condensation, small megakaryocytes with non-lobulated nucleous. BCR-ABL translocation were negative. The diagnosis has been established to abnormal chromatin clumping syndrome. Thereafter, the patient had an unexpected evolution. Initially classified as myelodysplastic syndrome, it has acquired a granulocytes proliferative character. So, it was reconsidered as a myelodysplastic/myeloproliferative neoplasm. Morphology remains fundamental at the beginning of the diagnostic algorithm for dysplasia
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