The periodontal disease represents an important oral health issue with impact on the quality of life. The oral health-related quality of life indicators are used to measure the impact of oral conditions on quality of life to complement clinical data.(1) The objective of this study was to review the studies referring to the quality of life in Romanian and Moldavian patients with oral conditions, especially those concerning the periodontal disease. A search was carried out on PubMed, Cochrane, Google, Google Academics, Web of Science and Scopus including the studies published between 2008 and 2018. A total of 13 studies was retained for which we obtained full-article access for further analysis. Among all studies, twelve (12) were observational, while one was a case-control study. The number of individuals tested varies between 50 and 865. We identified 8 instruments used to assess the quality of life and the most frequently used was OHIP 14 (7 times). All of the studies that assessed dental conditions reported a negative association with the health related quality of life. We have identified 3 studies published that estimate a lower quality of life in people with periodontal disease.(2,3,4) The degree of severity of the periodontal disease is proportional with decrease of the quality of life. In conclusion, periodontal disease has an important impact on general health and diminishes the quality of life as proven by various publications. We consider that the evaluation of quality of life related to oral health should be associated to a standard oral exam in order to perform a more complete patient evaluation. The OHIP 14 instrument could be a useful questionnaire to evaluate these groups of subjects.