The strategy of non-invasive coronary computed tomography angiography (CCTA) and subsequent invasive coronary angiography (ICA) has risks owing to repeated contrast medium administration (CMA) and the possibility of contrast-induced nephropathy (CIN). To assess CIN development, we retrospectively evaluated changes in the serum creatinine (sCr) level and estimated glomerular filtration rate (eGFR) (baseline, 24 hours after CMA, and 48 hours after the second CMA) in patients with repeated CMA. The study included 17 patients, and 7 (41.2%) had prior impaired renal function. The mean CCTA and ICA contrast medium volumes were 114.11 ± 7.75 ml and 129.7 ± 19.24 ml, respectively. The sCr level was higher and eGFR was lower at 48 hours after the second CMA than at baseline (p ≤ 0.05). However, CIN did not occur. Repeated CMA is not associated with CIN development at 48 hours after the second CMA, even in patients with prior impaired renal function.