The aim of this study is to highlight agents for therapy and prophylactic measures for dental caries in temporary dentition. Objectives of the study include identifying the needs of oral rehabilitation of children and the lack of information among parents and educators about oral hygiene and improving the oral health of preschool children through intervention studies that include brushing methods and skills. Materials and methods contain relevant articles of three databases: Academic Search Complete (via EBSCOhost), MedLine (via PubMed), E-nformation published prior to 12 June 2018. Results and discussions show that the total number of screened studies was 1946 and the number of eligible articles was 78. 33.3% of the studies investigated parents’ and educators’ knowledge about children’s oral health. Qualitative questionnaires were applied to parents and educators of children in public and private preschool educational systems. Interventional studies were found in the reviewed literature in 32% of cases. Conclusions: today’s literature contains a relevant number of studies regarding the oral health issues of preschool children. Our research highlights EbscoHost as a great online database with articles that match our theme.