Craving plays an important role in addiction and correlates with vulnerability to relapse and with the severity of alcohol dependence. The allostatic burden of chronic alcohol misuse in relation with genetic and environmental factors may explain craving and alcohol-seeking behaviours. Better understanding of the neurobiology and pathophysiology of craving may improve therapeutic approaches, thus reducing craving is becoming an increasingly valued perspective of treatments for alcohol use disorders. Here, we review some important aspects of neurobiology of craving and summarise some therapeutic implications targeting craving reduction.