FAECAL MICROBIOTA TRANSPLANT BEYOND THE GUIDELINES?
Abstract:
Clostridioides difficile infection (CDI) represents the most common cause of diarrheic
disease associated to public health services, an important public health problem due to the potential
risk of complications, severe forms of pseudomembranous colitis and death. Although the great
majority of CDI patients have a favourable response to specific antibiotic drug therapy, a significant
percentage will present one or several relapses and the risk of relapse increases with the increase in
numbers of infectious episodes, reaching 50-60% after the third CDI episode. Faecal microbiota
transplant (FMT) is a proven effective treatment method with high rates of curability in recurrent and
refractory CDI. However, can we use FMT earlier than the current recommendations of the treatment
guidelines? The evidence is beginning to pile up.
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