Chronic lymphocytic leukemia is still an incurable blood and bone marrow disease, but with a long and indolent rate of evolution. We present the case of a 56-year old male patient who was diagnosed with chronic lymphocytic leukemia, not requiring treatment. After 4 years of monitoring, his illness progressed with massive lymph nodes so we started treatment with chemotherapy. Due to several life-threatening respiratory infections, we needed to discontinue the treatment, but finally we managed to administer all the chemotherapy cycles. The patient relapsed several times and now he receives treatment with Ibrutinib. If the patient develops resistance to this inhibitor of Bruton’s tyrosine kinase, treatment with Venetoclax remains a future therapeutic option.