Colon cancer, a significant global health concern, exhibits various patterns of disease spread. Local invasion, characterized by the infiltration of tumor cells into adjacent tissues and organs, represents an important aspect of disease progression and management influencing treatment decisions and patient outcomes. Patients with locally advanced colon cancer may present a variety of clinical manifestations, including abdominal pain, bowel obstruction, changes in bowel habits, unexplained weight loss, or palpable masses. Physical examination, imaging and endoscopic evaluation are key components of the diagnostic workup. Histopathological examination of biopsied specimens provides definitive confirmation and helps determine the extent of local invasion. In addition to surgery, adjuvant therapies play a crucial role in the management of locally invasive colon cancer. Systemic chemotherapy, targeted therapies, and radiation therapy may be employed to reduce the risk of recurrence, control micro-metastatic disease, and enhance survival rates. Early recognition, accurate staging, and a multidisciplinary approach are essential for optimal management.