Healthcare-associated infections have an increased incidence, due to the antibiotic medication introduced without indication. Multiple infections with bacteria resistant to existing antibiotic medication occur, and the mortality rate given by these infections exponentially increases. Due to the increase in longevity of life, institutionalized which increases the incidence of HAI. The conduct developed in the programs to combat these infections must include activities for the prevention, surveillance, and training of medical staff in this regard. Several elaborate studies demonstrate the importance of staff education in terms of protection methods and show an exponential decrease in the occurrence of HAI. Continuous surveillance associated with infection control programs contributes to a better approach, to reducing healthcare costs, and the effort to improve the system. Specific activities need to be organized and supported at both regional and national levels, with extensive programs to prevent and combat the occurrence of resistant multi-drug infections.