THE MECHANISMS OF LIVER TOXICITY INDUCED BY ORGANIC SOLVENTS AND OTHER CHEMICAL COMPOUNDS
Abstract:
Occupational exposure to organic solvents and other chemicals often induces non-specific liver damage. Therefore, although the number of chemical hazards present in the workplace is high, the percentage of liver disease diagnosed or suspected to be work-related is rather low. This can be explained by the fact that, aside from some specific compounds, liver damage induced by exposures in occupational setting is like the one induced by other toxic substances. This review focuses on the mechanisms of liver toxicity initiated by occupational chemical hazards, detailing the conditions for toxicity, the role of structural topographical units, lesion determinations and pathogenic pathways, while also mentioning examples of workplaces that are at risk.
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