RELATION BETWEEN HOMOCYSTEINE LEVEL AND MACROANGIOPATHY IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Abstract:
Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease. In the specialty literature, there are studies which support the existence of a direct relationship between chronic kidney disease, homocysteine (Hcy) level and the risk of cardiovascular complications. The purpose of this study is to demonstrate whether the presence of angiopathic changes is associated with elevated levels of homocysteine in pre-dialysis patients with chronic kidney disease. Objective: the study aims to identify a correlation between homocysteine level and the occurrence of macroangiopathy in patients with chronic renal disease. We have studied 40 patients with chronic kidney disease, who were in pre-dialysis. A carotid Doppler echography was performed on each patient, the homocysteine value was determined. The lot was divided into two groups according to the chronic kidney disease rank. The relationship between homocysteine and angiography was assessed by Statistical Package for the Social Sciences (SPSS). Most patients in the study have elevated Hcy levels. 94% in lot I and lot II. Women who represent 40% of patients have higher values than men, and they also have a high frequency of atherosclerotic plaques. Hcy may be considered a cardiovascular risk factor in patients with chronic kidney disease.
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