Multiple biological parameters were proposed to evaluate the surgical stress response in the early postoperative period. Granulocyte/lymphocyte (G/L) ratio may be a useful marker and widely available. Measuring some of known surgical stress related markers together with G/L ratio we tried to confirm the superiority of laparoscopic approach and efficiency of the G/L ratio monitoring in this period. Materials and methods: 52 colorectal cancer patients who underwent elective surgery in a private clinical hospital were evaluated preoperatively and postoperatively (day 1 and day 5) for the: TNF-α, cortisol, C reactive protein (CRP) and G/L ratio. Results: Only CRP levels were significantly lower in the laparoscopy group in day 1 (74.07 vs 50.32, p=0.0461) and day 5 (18.37 vs 7.32, p=0.0001). The G/L ratio showed strong correlation with CRP levels in all measurements. Conclusions: Measurement of postoperative CRP levels confirmed the reduced surgical stress of laparoscopic colectomy for colorectal cancer in our clinic