SIGMOID COLON ADENOCARCINOMA IN A PATIENT WITH SYNCHRONOUS PROSTATE ADENOCARCINOMA WITH COMPLETE THERAPEUTIC RESPONSE: CASE REPORT AND LITERATURE REVIEW
Abstract:
Introduction: Over the last years, the incidence of multiple primary neoplasms has been
increasing, with cases of primary prostate cancer and primary colorectal cancer being one of the
most frequent. Case report: In the case of a 67-year-old patient with sigmoid cancer, a prostate
cancer was found in pre-therapeutic imaging evaluations, later confirmed by histopathological
examination. After colectomy with lymphadenectomy, he had received adjuvant chemotherapy, which
was stopped because of persistent thrombocytopenia. A prostatectomy with lymphadenectomy was
performed. After six months, Pet-PSMA showed bone lesions, so CyberKnife radiotherapy was
performed on each. After another six month-free interval, the patient presented biochemical
recurrence, so adjuvant “salvage” radiotherapy was performed with PSA value decreasing
afterwards. Without hormonal therapy, which was declined for the moment by the patient, after six
months, Pet-CT evidenced metastatic bone lesions and a secondary liver determination. Complete
androgenic blockade type hormone treatment has been initiated, as well as chemotherapy, with
imagistic complete response and stationary PSA value. Conclusions: In the cases of patients suffering
from multiple cancers, serial and multimodal treatments are the only one able to ensure their healing,
respectively their long-term survival
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